- Saint Andrews
- Saint Matthews
- Saint Stephen
- Salem
- Salley
- Saluda
- Sangaree
- Sans Souci
- Saxon
- Scotia
- Seabrook Island
- Sellers
- Seneca
- Seven Oaks
- Sharon
- Shell Point
- Shell Point
- Shiloh
- Silverstreet
- Simpsonville
- Six Mile
- Slater-Marietta
- Smoaks
- Smyrna
- Snelling
- Socastee
- Society Hill
- South Congaree
- South Sumter
- Southern Shops
- Springdale
- Springdale
- Starr
- Startex
- Stateburg
- Stuckey
- Sullivans Island
- Summerton
- Summit
- Sumter
- Surfside Beach
- Swansea
- Sycamore