- Saint Helena
- Saint James
- Saint Pauls
- Saint Stephens
- Salemburg
- Saluda
- Salvo
- Sandy Creek
- Sandyfield
- Sapphire Valley
- Saratoga
- Sawmills
- Saxapahaw
- Scotland Neck
- Scotts Mill
- Sea Breeze
- Seaboard
- Seagate
- Seagrove
- Sedalia
- Seven Devils
- Seven Lakes
- Seven Springs
- Shallotte
- Shannon
- Sharpsburg
- Shelby
- Sherrills Ford
- Siler City
- Silver City
- Silver Lake
- Simpson
- Sims
- Skippers Corner
- Smithfield
- Sneads Ferry
- Snow Hill
- South Gastonia
- South Henderson
- South Mills
- South Rosemary
- South Weldon
- Southern Pines
- Southern Shores
- Southmont
- Southport
- Sparta
- Speed
- Spencer
- Spencer Mountain
- Spindale
- Spiveys Corner
- Spring Hope
- Spring Lake
- Spruce Pine
- Staley
- Stallings
- Stanfield
- Stanley
- Stantonsburg
- Star
- Stedman
- Stem
- Stokes
- Stokesdale
- Stoneville
- Stonewall
- Stony Point
- Stovall
- Sugar Mountain
- Sugar Mountain Resort
- Summerfield
- Sunbury
- Sunset Beach
- Surf City
- Swannanoa
- Swanquarter
- Swansboro
- Swepsonville
- Sylva
